More than one-third (37 percent) of the contacted individuals reported using methamphetamine in the previous 30 days; more than half of these (58 percent) reported injection drug use. Methamphetamine users were more likely to be white, to engage in sex work, to inject drugs and to have sex partners who injected drugs. Users were also less likely to have used condoms when engaged in high-risk sexual behavior and were more likely than non-users to have used other drugs within the previous 30 days. Methamphetamine use among gay and bisexual males compounds risk for HIV, and risk-reduction interventions to this population should address both high-risk drug and sexual behaviors within the broader context of gay male communities. Tables, references