South Carolina is both a transit State and distribution area for illicit drugs on the East coast of the United States. Most drugs are transported into the State through private and commercial vehicles. This report focuses on the drugs cocaine, marijuana, methamphetamine, heroin, and other dangerous drugs. Cocaine, specifically crack cocaine, continues to pose the most serious threat to the State with its distribution and abuse frequently associated with violent crime. Marijuana is the most readily available and most commonly abused drug. However, it poses a lower threat than cocaine and is less often associated with violent crime. Methamphetamine poses the next most significant drug threat in the State with production and abuse showing an increase. Heroin constitutes a low threat to South Carolina. Its availability and abuse are concentrated in urban areas and coastal regions. Drugs, such as MDMA, GHB, ketamine, and LSD pose a low threat but are becoming an increasing threat to certain parts of the State. The outlook for the current assessed threat posed by these drugs is seen as remaining unchanged.