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NCJ Number: 207723 Find in a Library
Title: Treatment of Paraphilia in Young Adults with Leuprolide Acetate: A Preliminary Case Report Series
Journal: Journal of Forensic Sciences  Volume:49  Issue:6  Dated:November 2004  Pages:1343-1348
Author(s): Fabian M. Saleh M.D.; Trac y Niel M.A.; Marc J. Fishman M.D.
Date Published: November 2004
Page Count: 6
Publisher: http://www.astm.org 
Type: Case Study
Format: Article
Language: English
Country: United States of America
Annotation: This paper presents case reports on six young adult patients treated with leuprolide for a paraphilia, a psychiatric disorder characterized by a pervasive pattern of deviant and impairing sexual fantasies, thoughts, and/or behaviors.
Abstract: All of the subjects had been diagnosed with at least one paraphilia (pedophilia, sexual sadism, frotteurism, and paraphilia not otherwise specified). All had been in a residential program for adolescent sex offenders prior to being treated with leuprolide. They were selected for a trial with leuprolide after their evaluations and longitudinal indications suggested pharmacological treatment was appropriate. Leuprolide, a luteinizing hormone-releasing-hormone agonist (LHRH-A), is a testosterone-lowering agent that has been studied in patients with central precocious puberty, prostate cancer, and endometriosis. Since the early 1990's leuprolide has been used in treating patients with paraphilia and has gained growing acceptance partly because its side-effect profile is less severe than MPA. Moreover, leuprolide has apparently been effective with some patients who failed to respond to MPA or other similar agents. All six subjects reported a reduction in sexually deviant symptoms following treatment with leuprolide, which consisted of 7.5 mg/month and flutamide (250 mg p.o. TID for the first 14 days of treatment with leuprolide). Clinical response was rated subjectively by the treating physicians. Clinicians rated four subjects as much improved and two as moderately improved. Treatment was well tolerated by all subjects. These preliminary cases support the conclusion that leuprolide deserves further investigation as a possibly safe and effective component of treatment for young adults with paraphilia. 1 table and 26 references
Main Term(s): Juvenile Sex Offenders
Index Term(s): Prescription drugs; Sex offender treatment; Sex offenders; Treatment effectiveness; Young Adult (18-24); Young adult offenders
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http://www.ncjrs.gov/App/publications/abstract.aspx?ID=207723

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