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NCJ Number: 210949 Add to Shopping cart Find in a Library
Title: Baseline and Modulated Acoustic Startle Responses in Adolescent Girls With Posttraumatic Stress Disorder
Journal: Journal of the American Academy of Child & Adolescent Psychiatry  Volume:44  Issue:8  Dated:August 2005  Pages:807-814
Author(s): Deborah S. Lipschitz MBChB; Linda M. Mayes M.D.; Ann M. Rasmusson M.D.; Walter Anyan M.D.; Eileen Billingslea M.A.; Ralitza Gueorguieva Ph.D.; Steven M. Southwick M.D.
Date Published: August 2005
Page Count: 8
Sponsoring Agency: National Institute of Child Health and Human Development (NICHD)
Bethesda, MD 20892-2425
National Institute of Mental Health
Bethesda, MD 20852
National Institute on Drug Abuse
Bethesda, MD 20892-9561
Grant Number: K23MH01789;RO1DA06025;KO2DA0022;P01HD03008
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This study assessed baseline and modulated acoustic startle responses in adolescent girls with posttraumatic stress disorder (PTSD).
Abstract: In humans, one component of the acoustic startle response is a reflex eye blink that can be elicited with a sudden burst of noise of at least 90 dB, making the eye blink a common marker of the startle response because it can be easily recorded. An exaggerated startle response is a clinical feature often reported by patients with PTSD and is one of the hyperarousal or Criteria D symptoms of the DSM-IV diagnostic criteria for PTSD. The current testing of this alleged link between an exaggerated startle response and PTSD involved 28 adolescent girls with diagnosed PTSD and 23 healthy control girls. Both samples were exposed to bursts of white noise of 104 dB presented to both ears through headphones. The two groups of girls were compared on baseline startle responses as well as prepulse inhibition, a 1,000-Hz prestimulation tone presented continuously for 2,000 milliseconds before the startle stimulus. At baseline and under neutral testing conditions, the magnitude of the startle response (eye blink measurement) did not differ significantly between the two groups; and neither were there significant differences between the groups in the degree of prepulse inhibition or facilitation. These findings contrast with some studies (Butler et al., 1990; Orr et al., 1995; Shalev et al., 1992) but not all studies (Grillon et al., 1996, and Orr et al., 1997b) conducted with male combat veterans with PTSD. The findings of the current study, however, are similar to those in one other published study of acoustic startle response in traumatized women (Metzger et al., 1999). Possible explanations for the findings of the current study are discussed, along with clinical implications. 2 tables and 34 references
Main Term(s): Juvenile mental health services
Index Term(s): Adolescent females; Post-trauma stress disorder (PTSD); Psychological evaluation; Testing and measurement
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