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NCJ Number: 212914 Find in a Library
Title: Analysis of Carbohydrates in Seized Heroin Using Capillary Electrophoresis
Journal: Journal of Forensic Sciences  Volume:51  Issue:1  Dated:January 2006  Pages:39-44
Author(s): Ira Lurie M.S.; Patrick Hays B.S.; Ann Valentino B.S.
Date Published: January 2006
Page Count: 6
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: Since illicitly produced heroin is usually cut with carbohydrates to increase bulk, this paper reports on the effectiveness of using a capillary electrophoresis (CE) method for the qualitative analysis of the carbohydrates of interest (dextrose, lactose, sucrose, inositol, and mannitol).
Abstract: Although excellent separation was obtained for these five carbohydrates, the mannitol and inositol peak heights significantly decreased during multiple injections. Replacing the glass vials recommended by the manufacturer with plastic vials for the run buffer (Agilent Basic Anion Buffer) resulted in reproducible separations for the carbohydrates. For the CE method, a 64 cm (55.5 cm to detector window) by 50 mm capillary was used with the Agilent Basic Anion Buffer modified to pH 12.1. This separation was performed at 25 degrees centigrade with a voltage of 20kV and indirect detection with 2.6-pyridinedicarboxylic acid as the visualization reagent. This methodology is also applicable for the screening of inorganic and organic anions using indirect detection and acidic adulterants using direct detection. For a run time of 13 minutes, the relative standard deviation (n=6) of the methodology was better than 0.35 percent for migration times and less than 2.6 percent for corrected peak areas. 5 figures, 2 tables, and 18 references
Main Term(s): Police policies and procedures
Index Term(s): Drug analysis; Forensic sciences; Heroin; Investigative techniques
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