This strategy report is organized to build, balance, and integrate the tools of American power to combat transnational organized crime that threaten national security. The strategy provides five key policy objectives: protect Americans and partners from the harm, violence, and exploitation of transnational criminal networks; help partner countries strengthen governance and transparency, break the corruptive power of transnational criminal networks, and sever state-crime alliances; break the economic power of transnational criminal networks and protect strategic markets and the U.S. financial system from TOC penetration and abuse; defeat transnational criminal networks that pose the greatest threat to national security by targeting their infrastructures, depriving them of their enabling means, and preventing the criminal facilitation of terrorist activities; and build international consensus, multilateral cooperation, and public-private partnerships to defeat transnational organized crime. The strategy also introduces new and innovative capabilities and tools, which will be accomplished by prioritizing within the resources available to affected departments and agencies: a new Executive Order to establish a sanctions program to block significant transnational criminal networks; a proposed legislative package to help investigate, interdict, and prosecute the top transnational criminal networks; a new Presidential Proclamation under the Immigration and Nationality Act (INA) to deny entry to transnational criminal aliens; a new rewards program to obtain information that leads to the arrest and conviction of TOC leaders; an interagency Threat Mitigation Working Group to identify those TOC networks that present a sufficiently high national security risk and to ensure the coordination of all components.