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NCJ Number: 249389 Find in a Library
Title: GC-MS and IR Studies on the Six Ring Regioisomeric Dimethoxyphenylpiperazines (DOMePPs)
Journal: Journal of Forensic Sciences  Volume:60  Issue:2  Dated:March 2015  Pages:285-294
Author(s): Karim M. Abel-Hay; Jack DeRuiter; C. Randall Clark
Date Published: March 2015
Page Count: 10
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
Grant Number: 2011-DN-BX-K530
Document: HTML
Type: Report (Grant Sponsored); Report (Study/Research); Research (Applied/Empirical)
Format: Article; Document (Online)
Language: English
Country: United States of America
Annotation: In this study, a complete series of regioisomeric dimethoxyphenylpiperazines were synthesized and evaluated using GC-MS and FT-IR.
Abstract: A number of N-substituted piperazines have been described as drugs of abuse in recent years. This new drug category includes several series of aromatic ring substituted phenylpiperazines. The wide variety of available precursors makes regioisomerism a significant issue in these totally synthetic compounds. In the current study, the EI mass spectra showed fragments characteristic of both the dimethoxyphenyl and the piperazine portions of the molecules, including the dimethoxyphenylaziridinium cation (m/z 180) and dimethoxyphenyl cation (m/z 137). The ion at m/z 56 for the C3H6N+ fragment is characteristic of the piperazine ring and was observed in all the spectra. The perfluoroacyl derivatives were resolved by GC, and their mass spectra showed some differences in relative abundance of ions. FTIR provides direct confirmatory data for differentiation between the regioisomeric dimethoxyphenylpiperazines, and GC separation was accomplished on an Rtx-200 phase. (Publisher abstract modified)
Main Term(s): Drug research
Index Term(s): Designer drugs; Drug analysis; Drug law enforcement; Investigative techniques; NIJ grant-related documents; NIJ Resources
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