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NCJ Number: 250172 Find in a Library
Title: Dried Blood Spot Analysis as an Emerging Technology for Application in Forensic Toxicology
Author(s): Nicole Bynum; Katherine Moore; Megan Grabenauer
Date Published: August 2016
Page Count: 30
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
US Dept of Justice NIJ Pub
Washington, DC 20531
Grant Number: 2013-DN-BX-K017
Sale Source: US Dept of Justice NIJ Pub
810 Seventh Street, NW
Washington, DC 20531
United States of America
Document: PDF
Type: Report (Grant Sponsored); Report (Study/Research); Research (Applied/Empirical)
Format: Document; Document (Online)
Language: English
Country: United States of America
Annotation: This study assessed dried blood spot (DBS) analysis, which is well-established in newborn testing, for its application in forensic toxicology.
Abstract: Specifically, the study examined whether DBS could produce results comparable to traditional drug analysis and whether, when combined with mass spectrometry (MS), it is sufficiently sensitive for quantitation of the drugs of abuse typically encountered in forensic laboratories. The study focused on the current problems encountered in DBS analysis and the feasibility of its implementation in forensic laboratories. The assessment included, but was not limited to, stability, sensitivity, sample handling, extraction, and quantitation. The study found that quantitative LC/MS/MS results with DBS are all within recommended guidelines from such entities as the Society of Forensic Toxicologists, indicating that these results are comparable to well-established extraction methods for whole blood toxicology analyses. In addition, the project contributes to important method development parameters that must be considered prior to validating and implementing DBS analysis in the laboratory. DBS requires a small amount of sample, which is useful in cases for which there is limited sample. This impacts the judicial system by allowing for toxicological analysis of samples that may otherwise go untested. Small sample size also decreases the risk of exposure to blood-borne pathogens, making it safer for those involved in sample collection and analysis. 9 tables 5 figures, and a listing of presentations and planned publications on project findings
Main Term(s): Forensic sciences
Index Term(s): Blood/body fluid analysis; Drug overdose; Investigative techniques; NIJ final report; NIJ Resources; Poisons and poison analysis
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=272332

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