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NCJRS Abstract

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NCJ Number: 119030 Add to Shopping cart Find in a Library
Title: Mechanisms of Cocaine Abuse and Toxicity
Corporate Author: US Dept of Health, Education, and Welfare
Public Health Service
United States of America

US Dept of Health, Education, and Welfare
National Institute on Drug Abuse
United States of America
Editor(s): D Clouet; K Asghar; R Brown
Date Published: 1988
Page Count: 360
Sponsoring Agency: National Institute of Justice/
Rockville, MD 20849
NCJRS Photocopy Services
Rockville, MD 20849-6000
Superintendent of Documents, GPO
Washington, DC 20402
US Dept of Health, Education, and Welfare
Rockville, MD 20852
US Dept of Health, Education, and Welfare
Rockville, MD 20857
Publication Number: DHHS (ADM)88-1585
Sale Source: Superintendent of Documents, GPO
Washington, DC 20402
United States of America

National Institute of Justice/
NCJRS paper reproduction
Box 6000, Dept F
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF
Type: Report (Technical)
Language: English
Country: United States of America
Annotation: Two main problems in treating cocaine abusers, reversing or treating toxic effects of drug overdose and developing methods for dealing with the drug craving that leads to cocaine abuse, are reviewed in terms of their basic biomedical aspects.
Abstract: The review contains state-of-the-art knowledge of factors that influence drug-seeking behavior in laboratory animals, including drug vulnerability, basic neurochemical mechanisms, neuronal sites of the "reward" pathway, toxicology, perinatal consequences, and cardiovascular actions. Consideration is given to pharmacological effects of cocaine, cocaine receptors, sensitization to cocaine, behavioral aspects of the reinforcing properties of cocaine, and genetic differences in responses to cocaine. The seriousness of cocaine use in the United States is illustrated by 1985 population statistics that indicate an estimated 22 million persons had at least tried cocaine. The popularity of cocaine is underscored by figures on teenage use; over half of 1987 high school graduates had tried illicit drugs at least once, and slightly over 15 percent had used cocaine. Cocaine produces a number of physiological effects, including psychomotor stimulation, hypertension, tachycardia, anorexia, pupillary dilation, and euphoria. These effects are related to the two major actions of cocaine, local anesthesia effect and action on the central nervous system. References, tables, and figures.
Main Term(s): Cocaine
Index Term(s): Drug abuse; Drug effects; Toxic reactions
Note: NIDA Research Monograph 88, papers presented at a technical review meeting, Rockville, Md., September 21-23, 1987
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=119030

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