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NCJRS Abstract

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NCJ Number: 121313 Find in a Library
Title: Validity Testing of Commercial Urine Cocaine Metabolite Assays: III. Evaluation of an Enzyme-Linked Immunosorbent Assay (ELISA) for Detection of Cocaine and Cocaine Metabolite
Journal: Journal of Forensic Sciences  Volume:34  Issue:4  Dated:(July 1989)  Pages:991-995
Author(s): E J Cone
Date Published: 1989
Page Count: 5
Type: Test/Measurement
Format: Article
Language: English
Country: United States of America
Annotation: A validity assessment study was performed on the Genetic Diagnostic Enzyme Immunoassay test kit, a new enzyme-linked immunosorbent assay (GDC ELISA) for detection of cocaine and cocaine metabolite in urine.
Abstract: A set of 290 urine specimens, comprised of clinical cocaine urines collected from 5 male subjects who had received single doses of intravenous cocaine, drug-free urines spiked with cocaine, cocaine metabolites, cocaine isomers, and other drugs of abuse, were assayed by GDC ELISA. The results were compared with results by gas chromatography/mass spectrometry (GC/MS) assay for benzoylecgonine. Concordance was high between the GDC ELISA assay and GC/MS and with results reported earlier for other commercial assays. Detection times and specificity of the GDC ELISA antibody were most similar to those of the Abuscreen radioimmunoassay for cocaine metabolite. Overall, the assay produced no false negative or false positive results and appeared to be a reliable screening test for detection of cocaine and benzoylecgonine in human urine. (Author abstract)
Main Term(s): Drug testing
Index Term(s): Cocaine; Urinalysis
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