skip navigation


Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.


NCJ Number: 134470 Find in a Library
Title: Poisoning from Oral Ingestion of Carbofuran (Furadan 4F), a Cholinesterase-Inhibiting Carbamate Insecticide, and Its Effects on Cholinesterase Activity in Various Biological Fluids
Journal: Journal of Forensic Sciences  Volume:37  Issue:1  Dated:(January 1992)  Pages:337-344
Author(s): K E Ferslew; A N Hagardorn; W F McCormick
Date Published: 1992
Page Count: 8
Type: Report (Technical)
Format: Article
Language: English
Country: United States of America
Annotation: A case is presented of a fatal ingestion of Furadan (carbofuran), a cholinesterase-inhibiting carbamate insecticide.
Abstract: A 26-year-old white male was found dead with a partially filled 1-gal (3.8-L) container of Furadan 4F insecticide-nematocide (44.9 percent carbofuran). The individual had ingested approximately 345 mL of the mixture. Analysis of cholinesterase activity in various biological fluids was performed spectrophotometrically using propionylthiocholine and 5,5'-dithiobis-2 nitrobenzoic acid (Sigma Diagnostics, cholinesterase procedure No. 422 (PTC)) which was measured at 405 nm and 30 degrees Centigrade in a Gilford Stasar III Spectrophotometer. The cholinesterase activities were as follows: plasma, 245 units (U)/L (93 percent inhibition/7 percent normal activity); serum, 208 U/L (95.3 percent inhibition/4.7 percent normal activity); whole blood, 297 U/L (92.8 percent inhibition/7.2 percent normal activity); erythrocytes, 58 U/L (99 percent inhibition/1 percent normal activity); vitreous humor, 7 U/L; and bile, 148 U/L. Carbofuran was detected in the blood and gastric contents by thin-layer chromatography. No alcohol or other drugs were detected in the blood, urine, or gastric contents. Ingestion of the carbofuran produced acute visceral congestion and pulmonary edema. Death was caused by anoxia due to respiratory paralysis produced by cholinesterase inhibition from Furadan (carbofuran) ingestion. 9 references, 3 tables, and 1 figure (Author abstract)
Main Term(s): Poisons and poison analysis
Index Term(s): Blood/body fluid analysis; Death investigations; Hazardous substances or materials; Spectrophotometry; Victim identification
Note: Presented at the 43rd Annual Meeting of the American Academy of Forensic Sciences, 1991, Anaheim, California
To cite this abstract, use the following link:

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.