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NCJRS Abstract

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NCJ Number: 134639 Find in a Library
Title: Simultaneous Quantitation of Cocaine and Its Major Metabolites in Human Hair by Gas Chromotography/Chemical Ionization Mass Spectrometry
Journal: Journal of Analytical Toxicology  Volume:15  Dated:(September/October 1991)  Pages:260-265
Author(s): M R Harkey; G L Henderson; C Zhou
Date Published: 1991
Page Count: 6
Type: Research (Applied/Empirical)
Format: Article
Language: English
Country: United States of America
Annotation: This report describes a sensitive gas chromotography-chemical ionization mass spectrometry for the simultaneous quantitation of cocaine and benzoylecgonine (BE) and ecgonine methyl ester (EME), its major metabolites, in human hair.
Abstract: One-centimeter samples of hair from self-reported cocaine users were washed, rinsed with deionized water and methanol, and digested in an overnight solution. The digested samples were extracted with solid-phase extraction columns. This method is quantitative, requires a small sample of hair, and does not degrade the cocaine. There was little correlation between the concentration of cocaine in hair and self-reported drug use; the highest concentration was found in the hair of a moderate user and no cocaine was detected in the hair of a person who reportedly was a heavy cocaine user. The findings indicate that the concentration of cocaine in the hair is not solely determined by blood concentration of cocaine, but by other factors as well including type of drug, degree of ionization, and lipid solubility. Drugs may be absorbed into the hair from apocrine, sebaceous, or sweat gland secretions. 3 tables, 4 figures, and 32 references
Main Term(s): Cocaine; Hair and fiber analysis
Index Term(s): Chromatography; Mass spectroscopy
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