skip navigation


Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.


NCJ Number: 136017 Find in a Library
Title: Application of Empire C-8 Extraction Disks for Screening Urine in Systematic Toxicological Analysis
Journal: Journal of Forensic Sciences  Volume:37  Issue:2  Dated:(March 1992)  Pages:460-466
Author(s): K Ensing; J P Franke; A Temmink; X Chen; R A de Zeeuw
Date Published: 1992
Page Count: 7
Type: Test/Measurement
Format: Article
Language: English
Country: United States of America
Annotation: Empore extraction disks contain chemically modified C-8 reversed-phase silica embedded in an inert polytetrafluorethylene network. These extraction disks have been successfully applied for extraction and concentration of pesticides from groundwater; this study examines the applicability of these extraction disks for urine samples.
Abstract: Currently, solid-phase extraction by means of disposable columns has become a widely accepted technique for sample pretreatment in toxicology. In this method, however, the sample capacity is usually limited to a few milliliters. In this test of the extraction disks, human urine was selected as the matrix, and dexetimide and mepyramine were initially used as test drugs because they are available in tritiated form. Additional drugs investigated included codeine, hexobarbital, imipramine, methamphetamine, and nitrazepam. In these investigations, the sample capacity for untreated urine was at least 25 ml, and analyte quantities up to 250 mgs could be retained by these filters. Washing with water/methanol mixtures was effective in removing substantial amounts of endogenous interferences, and methanol proved to be an acceptable eluent. Thus, these disks apparently have the potential for toxicological analysis, in that sample concentration and cleanup can be achieved simultaneously. 3 figures, 1 table, and 7 references
Main Term(s): Urinalysis
Index Term(s): Blood/body fluid analysis; Drug detection; Drug testing
To cite this abstract, use the following link:

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.