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NCJRS Abstract

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NCJ Number: 136017 Find in a Library
Title: Application of Empire C-8 Extraction Disks for Screening Urine in Systematic Toxicological Analysis
Journal: Journal of Forensic Sciences  Volume:37  Issue:2  Dated:(March 1992)  Pages:460-466
Author(s): K Ensing; J P Franke; A Temmink; X Chen; R A de Zeeuw
Date Published: 1992
Page Count: 7
Type: Test/Measurement
Format: Article
Language: English
Country: United States of America
Annotation: Empore extraction disks contain chemically modified C-8 reversed-phase silica embedded in an inert polytetrafluorethylene network. These extraction disks have been successfully applied for extraction and concentration of pesticides from groundwater; this study examines the applicability of these extraction disks for urine samples.
Abstract: Currently, solid-phase extraction by means of disposable columns has become a widely accepted technique for sample pretreatment in toxicology. In this method, however, the sample capacity is usually limited to a few milliliters. In this test of the extraction disks, human urine was selected as the matrix, and dexetimide and mepyramine were initially used as test drugs because they are available in tritiated form. Additional drugs investigated included codeine, hexobarbital, imipramine, methamphetamine, and nitrazepam. In these investigations, the sample capacity for untreated urine was at least 25 ml, and analyte quantities up to 250 mgs could be retained by these filters. Washing with water/methanol mixtures was effective in removing substantial amounts of endogenous interferences, and methanol proved to be an acceptable eluent. Thus, these disks apparently have the potential for toxicological analysis, in that sample concentration and cleanup can be achieved simultaneously. 3 figures, 1 table, and 7 references
Main Term(s): Urinalysis
Index Term(s): Blood/body fluid analysis; Drug detection; Drug testing
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=136017

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