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NCJRS Abstract

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NCJ Number: 136033 Find in a Library
Title: Comparison of Abbott Fluorescence Polarization Immunoassay (FPIA) and Roche Radioimmunoassay for the Analyses of Cannabinoids in Urine Specimens
Journal: Journal of Forensic Sciences  Volume:37  Issue:2  Dated:(March 1992)  Pages:632-635
Author(s): W T Budgett; B Levine; A Xu; M L Smith
Date Published: 1992
Page Count: 4
Type: Test/Measurement
Format: Article
Language: English
Country: United States of America
Annotation: Abbott fluorescence polarization immunoassay (FPIA) and Roche Abuscreen radioimmunoassay (RIA) were compared qualitatively with 142 urine specimens that contained 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid, the major urinary metabolite of marijuana.
Abstract: A total of 142 specimens were analyzed by FPIA and RIA using the 100-ng/ml cut-off. The samples represented a range of concentrations above and below this administrative screening cut-off. Of the 142 specimens tested, 132 generated the same qualitative results. All specimens negative by FPIA and positive by RIA were within 20 percent of the cut-off, and seven of the nine specimens were within 10 percent of the cut-off. Similarly, the RIA counts per minute of the specimens negative by RIA and positive by FPIA were within 10 percent of the counts per minute produced by the cut-off calibrator. These data suggest that the RIA antibody might have slightly broader specificity in screening for cannabinoids; however, this slight difference is not significant. The study concludes that either of these immunoassays could be used singularly in a mass drug-screening laboratory and generate comparable results. 1 table, 1 figure, and 3 references
Main Term(s): Urinalysis
Index Term(s): Comparative analysis; Drug testing; Marijuana
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=136033

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