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NCJRS Abstract

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NCJ Number: 164698 Find in a Library
Title: Buprenorphine as a Pharmacotherapy for Opiate Addiction: What Dose Provides a Therapeutic Response?
Journal: American Journal on Addictions  Volume:5  Issue:3  Dated:(Summer 1996)  Pages:220-230
Author(s): P A Compton; D R Wesson; V C Charuvastra; W Ling
Date Published: 1996
Page Count: 11
Type: Survey
Format: Article
Language: English
Country: United States of America
Annotation: Pharmacological response criteria were used to determine the therapeutic dose range of buprenorphine for the treatment of opiate drug dependence.
Abstract: One hundred consecutively admitted patients with opiate addiction were followed for 16 weeks while receiving a daily, double-blinded buprenorphine dose between 4 and 32 milligrams. Pharmacological response was determined in terms of a composite score that reflected urine toxicology, clinic attendance, and withdrawal or toxicity symptomatology. Results revealed that 34 participants met pharmacological response criteria at an average daily dose of 14.6 milligrams, plus or minus 6.5 milligrams. Thus, the therapeutic dose was somewhat higher than that used in recent efficacy studies. Figures and 24 references (Author abstract modified)
Main Term(s): Drug treatment
Index Term(s): Drug dependence; Drug detoxification
Note: DCC
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