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NCJ Number: 165655 Add to Shopping cart Find in a Library
Title: Cocaine Addiction: Hypothesis Derived From Imaging Studies with PET (From Neurobiology of Cocaine Addiction: From Bench to Bedside, P 55-71, 1996, Herman Joseph and Barry Stimmel, eds. -- See NCJ-165651)
Author(s): N D Volkow; Y-S Ding; J S Fowler; G-J Wang
Date Published: 1996
Page Count: 17
Sponsoring Agency: Haworth Press, Inc
Binghamton, NY 13904
National Institute on Drug Abuse
Bethesda, MD 20892-9561
US Dept of Energy
Washington, DC 20585
Grant Number: 5RO1-DA06891; 1RO1-DA09490-01
Contract Number: DE-ACO2-76CH00016
Sale Source: Haworth Press, Inc
10 Alice Street
Binghamton, NY 13904
United States of America
Type: Research (Applied/Empirical)
Language: English
Country: United States of America
Annotation: Analysis of the behavior of cocaine in the human brain with Positron Emission Tomography (PET) revealed cocaine's affinity for the dopamine transporter and its fast pharmacokinetics give cocaine unique properties.
Abstract: The authors postulated that certain pharmacological properties of cocaine would trigger the pathological activation of a cerebral circuit that enabled the maintenance of behaviors required to achieve a targeted biological goal. The PET imaging technique was used to measure the concentration of positron emitter labeled compounds in the living brain. Two approaches were employed: (1) characterize cocaine binding in the baboon brain and investigate its pharmacokinetics in the human brain; and (2) compare cocaine behavior with that of methylphenidate, a drug which inhibits the dopamine transporter like cocaine but which is abused in humans much less frequently than cocaine. Results showed that the very fast uptake and clearance of cocaine from the brain contrasted with that of methylphenidate. Methylphenidate cleared from the brain at a much slower rate and was less addictive than cocaine. The authors believe periodic and frequent stimulation of the dopaminergic system secondary to chronic cocaine use favors activation of a circuit that involves the orbitofrontal cortex, cingulate gyrus, thalamus, and striatum. This circuit is abnormal in cocaine abusers, perpetuates compulsive cocaine administration, and is perceived by the cocaine abuser as a more intense desire resulting in the loss of control over the drive to use more cocaine. 49 references, 1 table, and 6 figures
Main Term(s): Drug effects
Index Term(s): Biological influences; Cocaine; Drug abuse; Drug dependence; Drug research
Note: DCC
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