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NCJ Number: 166330 Add to Shopping cart Find in a Library
Title: Protocol To Switch High-Dose Methadone-Maintained Subjects to Buprenorphine
Journal: American Journal on Addictions  Volume:6  Issue:2  Dated:(Spring 1997)  Pages:105-116
Author(s): F R Levin; M W Fischman; I Connerney; R W Foltin
Date Published: 1997
Page Count: 12
Sponsoring Agency: National Institute on Drug Abuse
Bethesda, MD 20892-9561
National Institutes of Health
Bethesda, MD 20014
Grant Number: 1K20DA00214-01A1; DA-06234; MOI-RR-00645
Type: Survey
Format: Article
Language: English
Country: United States of America
Annotation: The possibility of using buprenorphine (BUP) as an alternative to methadone (METH) was studied using 18 volunteers in an inpatient setting.
Abstract: The research was prompted by other findings suggesting that BUP is less preferred in humans than heroin and may have less abuse potential than heroin or other commonly prescribed opiate medications. It also produces less respiratory depression and has other advantages over METH. The participants all had histories of heroin and intravenous cocaine use. They had been maintained on METH for 1-19 years and were recruited for a residential cocaine self-administration study. They were all maintained on 60 mg METH for up to 1.5 weeks before the 7-day changeover. The changeover involved 60, 40, 30, and 0 mg METH and then 4 and 8 mg BUP. Fifteen participants successfully completed the transfer from METH to BUP; they experienced moderate withdrawal symptoms as measured by the Subjective Opiate Withdrawal Scale. Withdrawal symptoms were the highest during the first assessment of the day, at the time of BUP administration. Their symptom scores returned to baseline 4 days after the switchover. Findings demonstrated that research volunteers in a supportive inpatient setting can be rapidly switched from high-maintenance doses of METH to BUP with an acceptable degree of tolerability. Figures and 29 references (Author abstract modified)
Main Term(s): Drug treatment
Index Term(s): Methadone maintenance
Note: DCC
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