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NCJ Number: 181956 Find in a Library
Title: Development of the Human Y Chromosome as a Forensic Tool, Final Progress Report
Author(s): Michael F. Hammer; Susan D. Narveson
Date Published: 2000
Page Count: 9
Sponsoring Agency: National Institute of Justice (NIJ)
Washington, DC 20531
NCJRS Photocopy Services
Rockville, MD 20849-6000
University of Arizona
Tucson, AZ 85721
Grant Number: 97-LB-VX-0010
Sale Source: University of Arizona
Tucson, AZ 85721
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF
Type: Report (Technical)
Format: Document
Language: English
Country: United States of America
Annotation: This study was conducted to develop a set of male-specific markers for use in forensic typing laboratories.
Abstract: Main study goals were to identify a set of polymorphic markers mapping to the nonrecombining portion of the Y chromosome (NRY) that are robust in forensic analysis; to develop detailed protocols for high throughput, fluorescence-based typing of these markers; and to establish an NRY database for U.S. population groups. Several tri-, tetra-, and penta-nucleotide repeats exhibited robust amplification without artifactual banding and did not produce high- frequency alleles in all populations. Toward the goal of establishing an NRY polymorphism database, the researchers genotyped five Y-micro-satellites in a panel of 1,141 individuals representing 5 U.S. population groups (Southwest Hispanic, Caucasian, African American, Native American, and East Asian) and 15 populations from Asia, Europe, and the Americas. Six additional Y-micro-satellites were genotyped in a subset of the U.S. population groups. All 1,141 individuals were also genotyped at 31 bi-allelic polymorphisms on the NRY. The NRY was useful in identifying population-specific Y-chromosome haplotypes, while Y-micro-satellites and combination haplotypes provided a high degree of individualization among male lineages within populations. Results demonstrated the importance of considering the potential impact of both population structure and admixture among U.S. groups on the statistical analysis of Y-chromosome forensic data. 8 references, 7 tables, and 3 figures
Main Term(s): Police research
Index Term(s): American Indians; Asia; Asian Americans; Biological influences; Black/African Americans; Caucasian/White Americans; Crime laboratories; Criminal investigation; Criminalistics; DNA fingerprinting; Europe; Evidence identification; Forensic sciences; Hispanic Americans; Latin America; Male offenders; NIJ grant-related documents; United States of America; US/foreign comparisons
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