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NCJ Number: 182838 Find in a Library
Title: Pharmacology: Forensic Aspects of Drug Interactions, Part II
Journal: Forensic Examiner  Volume:8  Issue:11-12  Dated:November/December 1999  Pages:137-167
Author(s): Peter D. Anderson
Editor(s): Daphne Greenlee
Date Published: 1999
Page Count: 4
Type: Report (Technical)
Format: Article
Language: English
Country: United States of America
Annotation: This article discusses types of legal cases in which drug interactions are relevant, factors to consider when reviewing a case involving a drug interaction, examples of drug interactions, and clinical management of drug interactions.
Abstract: Drug interactions may be relevant in malpractice litigation, death or injury related to alleged intoxication, driving under the influence, homicides, suicides, and drug testing. Physicians, pharmacists, and nurses may be liable for failure to detect drug interactions. Further, drug interactions are relevant to substance abuse forensic work, and drug interactions need to be considered in death and suicide investigations. In analyzing drug interactions, forensic examiners should be careful when interpreting drug levels that are above or below the therapeutic range, especially since certain patients require higher or lower levels than the standard therapeutic range. Specific drug interactions are described for astemizole, monoamine oxidase inhibitors, serotonin, HIV protease inhibitors, theophylline, and ethanol. Four considerations in managing drug interactions are identified: (1) certain combinations of drugs are contraindicated and should never be given concurrently; (2) many drug interactions can easily be circumvented; (3) alternative drugs with less risk of interaction should be used; and (4) patient risk should be assessed and precautions should be taken to avoid adverse outcomes. 26 references
Main Term(s): Police
Index Term(s): Death investigations; Drug abuse; Drug effects; Drug related fatalities; Drug testing; Drug use; Forensic medicine; Forensic sciences; Malpractice litigation; Medical malpractice; Suicide; Toxic reactions
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