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NCJ Number: 183353 Add to Shopping cart Find in a Library
Title: Lifetime Tobacco, Alcohol and Other Substance Use in Adolescent Minnesota Twins: Univariate and Multivariate Behavioral Genetic Analyses
Journal: Addiction  Volume:94  Issue:7  Dated:July 1999  Pages:981-993
Author(s): Cong Han; Matthew K. McGue; William G. Iacono
Date Published: July 1999
Page Count: 13
Sponsoring Agency: SAMHSA Ctr for Substance Abuse Prevention (CSAP)
Rockville, MD 20847
Grant Number: DA05147;AA09367;AA00175
Type: Report (Study/Research)
Format: Article
Language: English
Country: United Kingdom
Annotation: This study estimated the contribution of genetic and environmental factors to adolescent tobacco, alcohol, and other substance use.
Abstract: The sample consisted of 327 monozygotic and 174 like-sex dizygotic twin pairs born in Minnesota and aged 17-18 years at the time of assessment. Biometrical methods were used to estimate the contribution of additive genetic, shared, and non-shared environmental factors to adolescent substance use. As part of a day-long psychological assessment, adolescent twins completed a computerized substance-use interview to determine whether they had ever used tobacco, alcohol, or other illicit drugs. The heritability for the liabilities to tobacco, alcohol, and other drug use was estimated to be 59 percent, 60 percent, and 33 percent among males, and 11 percent, 10 percent, and 11 percent among females; however, the gender differences were not statistically significant. Estimates of shared environmental effect were substantial and insignificantly higher among females (71 percent, 68 percent, and 36 percent, respectively) than among males (18 percent, 23 percent, and 23 percent, respectively). The covariation among the three substance use phenotypes could be accounted for by a common underlying substance-use factor. Estimates of the contributions of genetic, shared environmental, and non-shared environmental factors to variance in this factor were 23 percent, 63 percent, and 14 percent, respectively. These findings add to the growing behavioral genetic literature that indicates adolescent initiation of substance use, a powerful predictor of adult substance use, is influenced primarily by environmental rather than genetic factors. 5 tables, 2 figures, and 48 references
Main Term(s): Juvenile drug use
Index Term(s): Biological influences; Drug abuse causes; Environmental influences; Juvenile delinquency factors; Minnesota; Tobacco use; Twins as research subjects; Underage Drinking
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