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NCJ Number: 192859 Find in a Library
Title: Signal Transduction Mechanisms and Behavioral Sensitization to Stimulant Drugs: An Overview of cAMP and PLA2
Journal: Journal of Addictive Diseases  Volume:20  Issue:3  Dated:2001  Pages:33-42
Author(s): Douglas L. Gelowitz Ph.D.; S. Paul Berger M.D.
Date Published: 2001
Page Count: 10
Type: Report (Technical)
Format: Article
Language: English
Country: United States of America
Annotation: This article discusses intracellular, signal transduction mechanisms (cAMP and PLA2) relevant to behavioral sensitization to stimulant drugs in connection with the development of drug dependence.
Abstract: Behavioral sensitization involves the progressive increase of behavioral responses to psychomotor stimulants and provides a model for the intensification of drug craving and relapse alleged to underlie addiction in humans. Mechanisms related to sensitization may also contribute to schizophrenia and bipolar disorder. The phenomenon of behavioral sensitization has been observed for years. However, studies have only recently focused molecular or intracellular mechanisms associated with behavioral sensitization. The activation of PLA2 and cAMP signal transduction pathways within mesolimbic dopamine neutons, at the level of the nucleus accumbens and ventral tegmental area, may have a crucial role in the development of behavioral sensitization. However, few studies have directly studied the effects of PLA2 and cAMP on behavioral sensitization. Therefore, future research should address this issue. 61 references (Author abstract modified)
Main Term(s): Drug dependence
Index Term(s): Biological influences; Drug abuse causes; Drug effects; Problem behavior
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