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NCJ Number: 193257 Find in a Library
Title: Bioterrorism-Related Inhalational Anthrax: The First 10 Cases Reported in the United States
Journal: Emerging Infectious Diseases  Volume:7  Issue:6  Dated:November-December 2001  Pages:933-944
Author(s): John A. Jernigan; David S. Stephens; David A. Ashford; Carlos Omenaca; Martin S. Topiel; Mark Galbraith et al
Date Published: November 2001
Page Count: 12
Document: PDF
Type: Research Paper
Format: Article
Language: English
Country: United States of America
Annotation: This article studies the first 10 cases of inhalational anthrax reported in the United States.
Abstract: From October 4 to November 2, 2001, the Centers for Disease Control and Prevention and State and local public health authorities reported 10 confirmed cases of inhalational anthrax and 12 confirmed or suspected cases of cutaneous anthrax. The outbreak resulted from intentional delivery of Bacillus anthracis spores through mailed letters or packages. The article includes medical history data, disease symptoms, and treatment for each of the 10 individuals. Their clinical presentation was variable and often resembled a viral respiratory illness, but the interpretation of the initial symptoms in the context of a possible exposure to Bacillus anthracis led to an early diagnosis. Survival may be markedly improved by combination antimicrobial therapy begun during the initial phase of the illness and by aggressive supportive care (e.g., drainage of pleural effusions). The article describes newer methods of detection such as polymerase chain reaction, immunohistochemistry, and sensitive serologic tests as important adjunctive diagnostic modalities that aid in the diagnosis of Bacillus anthracis infections. The article concludes that studies are needed to further define optimal antimicrobial regimens, explore the role of adjunctive therapies, and better understand the pathogenesis of inhalational anthrax associated with intentional release. Tables, figures, references
Main Term(s): Biological weapons
Index Term(s): Communicable diseases; Diseases; Domestic Preparedness; Medical Readiness; Science and Technology; Scientific techniques; Terrorist weapons; Testing and measurement; Treatment
Note: Downloaded February 26, 2002
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