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NCJ Number: 202378 Find in a Library
Title: Treating Impulsivity, Irritability, and Aggression of Antisocial Personality Disorder with Quetiapine
Journal: International Journal of Offender Therapy and Comparative Criminology  Volume:47  Issue:5  Dated:October 2003  Pages:556-567
Author(s): Candace Walker; Janice Thomas; Timothy S. Allen
Editor(s): George B. Palermo M.D.
Date Published: October 2003
Page Count: 12
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This paper examines the treatment of antisocial personality disorder (APD) patients using Quetiapine through the reporting of the results of treatment with Quetiapine in four case studies.
Abstract: There are few effective treatments for antisocial personality disorder (APD) which is characterized by impulsivity, irritability, and aggression. This paper describes four case reports of patients referred to a maximum-security inpatient forensic psychiatric facility for pretrial evaluation and treated with the atypical antipsychotic agent Quetiapine. All four patients met the criteria for APD and were severely psychopathic. The case reports consisted of a 39-year old man convicted of murders as a teenager, a 35-year old man with a history of aggressive behavior, a 19-year old man with severe aggressive behavior, and a 23-year old man who was convicted of murder in middle adolescence. Quetiapine is used in this facility based on its favorable safety and tolerability profile in psychotic patients. Patients showed a decrease in symptoms with a typical daily dosage of 600 to 800 milligrams. Treatment in the four patients produced substantial improvements in important behavioral aspects of psychopathy. References
Main Term(s): Deviance
Index Term(s): Antisocial attitudes; Behavior modification; Controlled Substances; Drug effects; Drug research; Medical research; Personality assessment; Prescription drugs; Psychological evaluation
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