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NCJ Number: 218477 Find in a Library
Title: Apparent Effects of Glyphosate on Alkaloid Production in Coca Plants Grown in Colombia
Journal: Journal of Forensic Sciences  Volume:52  Issue:3  Dated:May 2007  Pages:573-578
Author(s): John Casale B.S.; John Lydon Ph.D.
Date Published: May 2007
Page Count: 6
Publisher: http://www.blackwellpublishing.com/ 
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: During the routine analysis of coca leaf material from Colombia, alkaloids in Erythroxylum coca var. ipadu (ECVI) leaf samples from fields suspected of being treated with glyphosate (a nonselective, broad-spectrum, postemergence herbicide used in spraying coca fields) were compared with those from nontreated ECVI and Erythroxylum novogranatense var. novogranatense (ENVN) plants.
Abstract: An unusual alkaloid profile was observed for coca leaf tissue obtained from six field sites in the Putumayo Region of Colombia. A program to control coca leaf production with the aerial spraying of glyphosate on coca fields was known to exist in this area, and local farmers reported that the fields from which the coca leaf tissue came were sprayed aerially. This suggests that the plants in the six fields had been treated with glyphosate before harvest. The alkaloid levels in the leaf tissue from these fields, particularly the reduced production of 3beta-benzoylated tropane alkaloids, such as cocaine, are consistent with the disruption in plant metabolism by a herbicide such as glyphosate. The herbicide alters the shikimic acid pathway. Leaves from treated plants were nearly devoid of cocaine. On the other hand, cocaine levels in leaf tissue from nontreated ECVI and ENVN were 0.53 (plus or minus 0.08 percent) and 0.64 (plus or minus 0.08 percent), respectively. Further analysis showed the presence of several previously undescribed N-nortopane alkaloids, several of which were tentatively identified. These results suggest that applications of glyphosate to coca plants can have dramatic effects on the quantity and quality of alkaloids produced by surviving or subsequent leaves. The description of materials and methods addresses plant material; solvents, chemicals, standards, and materials used in the chemical analysis; the isolation and quantitation of alkaloids; and the gas chromatography-mass spectrometry. 5 figures and 19 references
Main Term(s): Police policies and procedures
Index Term(s): Cocaine; Colombia; Drug eradication programs; Effectiveness of crime prevention programs; Foreign drug law enforcement
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=240178

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