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NCJRS Abstract

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NCJ Number: 219308 Find in a Library
Title: MDMA, Methamphetamine and Their Combination: Possible Lessons for Party Drug Users From Recent Preclinical Research
Journal: Drug and Alcohol Review  Volume:26  Issue:1  Dated:January 2007  Pages:9-15
Author(s): Kelly J. Clemens; Iain S. McGregor; Glenn E. Hunt; Jennifer L. Cornish
Date Published: January 2007
Page Count: 7
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This article discusses recent findings concerning the acute and long-term effects of MDMA and methamphetamine (METH) and their combination in laboratory animals and the possible implications of these results for human users.
Abstract: Substantial progress has been made in recent years in employing animal models to characterize both the acute and the lasting effects of MDMA and methamphetamine (METH) on brain and behavior. Important recent findings made with animal models that inform the human situation include: (1) the greater tendency towards compulsive use of METH compared to MDMA, (2) the unique pro-social effects of MDMA and the neuroendocrine basis of this effect, (3) the ability of high ambient temperatures to modulate the rewarding properties of MDMA and METH, (4) the functional and emotional impairments observed in rats previously exposed to MDMA and METH, and (5) the likely synergistic adverse effects of combining MDMA and METH. This review underscores the utility of animal models in elucidating the neural substrates and environmental factors that drive MDMA and METH use and in providing a clear and realistic appraisal of the likely long-term hazards arising from exposure to these drugs. Recent concern has developed over the trend for users to combine the ingestion of MDMA and METH within the same drug-taking episode, either intentionally or inadvertently). As both have been independently linked to long-term adverse neural and behavioral effects, it is conceivable that the combination of the two drugs may be particularly harmful. 1 figure, 70 references
Main Term(s): Drug effects
Index Term(s): Amphetamines; Drug abuse; Drug analysis; Drug testing; MDMA (designer drug); Poisons and poison analysis; Toxic reactions
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