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NCJRS Abstract

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NCJ Number: 221359 Find in a Library
Title: Rapid Electronic Detection of DNA and Nonnatural DNA Analogs for Molecular Marking Applications
Author(s): Arica A. Lubin; Chunhai Fan; Morgan Schafer; Catherine Taylor Clelland; Carter Bancroft; Alan J. Heeger; Kevin W. Plaxco
Date Published: January 2008
Page Count: 13
Sponsoring Agency: US Dept of Justice Federal Bureau of Investigation
Quantico, VA 22135
Sale Source: US Dept of Justice Federal Bureau of Investigation
Laboratory Branch
2501 Investigation Parkway
Quantico, VA 22135
United States of America
Document: HTML
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This study shows the feasibility of using a reagentless, electronic method of detecting hybridization (termed E-DNA) in order to detect identifying DNA and locked nucleic acid (LNA, a more stable, secure nonnatural DNA analog) markers embedded in documents, pharmaceuticals, consumer goods, and tissue samples.
Abstract: The study found that this approach obtained results within minutes and detected marker levels as low as parts per billion. Also, the molecular markers are stable for long-term storage under ambient conditions. These attributes indicate that the E-DNA-based detection of nucleic acid molecular markers will prove useful in a wide range of forensic applications. The use of molecular markers as physical labels has been widely applied in tasks that range from the forensic identification of explosives, the identification of counterfeit merchandise, and the tracing of ground water. One marking method has focused on the unique coding abilities inherent in natural and nonnatural nucleic acids, such as DNA. To date, however, the use of these markers has been hampered by the relatively cumbersome methods required for the sequence-specific detection of small quantities of DNA embedded in complex, contaminant-ridden samples, along with the marker's relative instability against biological degradation. The E-DNA sensor provides a convenient solution to this problem. This report provides a detailed description of the reagents, the preparation and characterization of E-DNA sensors, and marking and detection. 50 references
Main Term(s): Criminology
Index Term(s): DNA fingerprinting; Document analysis; Drug analysis; Forensic sciences; Investigative techniques
Note: From Forensic Science Communications, N 1, V 10, January 2008; downloaded January 24, 2008.
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