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NCJRS Abstract

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NCJ Number: 221429 Find in a Library
Title: Characterisation of the STR Markers DXS10146, DXS10134 and DXS10147 Located Within a 79.1 kb Region at Xq28
Journal: Forensic Science International Genetics  Volume:2  Issue:1  Dated:January 2008  Pages:41-46
Author(s): Jeanett Edelmann; Sandra Hering; Christa Augustin; Reinhard Szibor
Date Published: January 2008
Page Count: 6
Type: Report (Study/Research)
Format: Article
Language: English
Country: Ireland
Annotation: This study describes three STR markers which were molecularly characterized and evaluated for forensic usage.
Abstract: The results found three polymorphic X-chromosomal STR markers within a 79kb region at Xq28, which were subsequently registered in the GDB as DXS10146, DXS10134, and DXS10147. The three markers to the X-chromosomal panel can be used for haplotyping. As a result, DXS10134 was recently integrated in the commercially available test kit, Mentype Argus X-8. In males and in certain pedigree situations, typing of closely linked STRs can establish haplotypes which are able to substitute single STR data, as well as provide highly informative tools for kinship testing. Internet databases were examined for clusters of linked ChrX microsatellites before establishing the haplotyping approach using linked markers. It was possible to find clusters consisting from slightly tight linked STRs which span only very few centimorgans. Moreover, the most recent attempts were aimed at establishing haplotypes consisting of very closely linked markers nearly free of recombination. For such purposes, GenBank sequences for unidentified STRs were screened, and candidates were selected according to their structure, polymorphic degree and localization. STRs from different regions on the ChrX were investigated such as Xp22, Xp11, and Xq28 in order to study the Xq28 STR cluster. The sample included a population of 404 German males, and revealed 311 haplotypes. Recombination analysis was performed in 109 father-daughter-grandson trios, in which two crossing over events were observed located in the 65.8kb region, between DXS10146 and DXS10134. By using this STR complex for haplotyping in kinship testing, further genetic analyses are required to establish an exact recombination rate. Tables, references
Main Term(s): Blood/body fluid analysis; Forensic sciences; Germany
Index Term(s): Evaluation; Medical research
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