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NCJ Number: 222073 Find in a Library
Title: Nature of Tri-Allelic TPOX Genotypes in African Populations
Journal: Forensic Science International: Genetics  Volume:2  Issue:2  Dated:March 2008  Pages:134-137
Author(s): A.B. Lane
Date Published: March 2008
Page Count: 4
Type: Report (Technical)
Format: Article
Language: English
Country: United States of America
Annotation: This study examined the nature and the time of origin of the duplication that is responsible for the tri-allelic TPOX genotypes in the African populations.
Abstract: The fact that a variety of bi-allelic combinations were transmitted to tri-allelic offspring suggests that the duplicated allele is not close to the TPOX locus. Also, there was apparent linkage equilibrium between the duplication locus and the main TPOX locus. The excess of tri-allelic females and the finding that tri-allelic males never transmit two alleles (alternative genes) to their sons but always transmit two alleles to their daughters strongly suggests that the duplicated allele is on an X chromosome. Approximately 2.4 percent of indigenous South Africans have three rather than two TPOX alleles. This study attempted to shed light on the nature and time of origin of the duplication responsible for the commonly observed tri-allelic TPOX genotypes in the South African population. Tables, figure, references
Main Term(s): Forensic sciences; South Africa
Index Term(s): Biological influences; Chromosomal abnormalities; Ethnic groups
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