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NCJ Number: 222200 Find in a Library
Title: From Population- to Subject-Based Limits of T/E Ratio to Detect Testosterone Abuse in Elite Sports
Journal: Forensic Science International  Volume:174  Issue:2-3  Dated:January 2008  Pages:166-172
Author(s): Pierre-Edouard Sottas; Christophe Saudan; Carine Schweizer; Norbert Baume; Patrice Mangin; Martial Saugy
Date Published: January 2008
Page Count: 7
Sponsoring Agency: Swiss National Science Foundation (SNSF)
Grant Number: 320000-111771
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: In order to determine whether a better interpretation of the testosterone/epitestosterone (T/E) ratio can enhance the detection of testosterone abuse, this study selected 12 case studies to represent various scenarios to which antidoping laboratories are confronted for detecting testosterone abuse in elite athletes; the relationship between the sensitivity and the specificity was calculated for the different approaches.
Abstract: The study found that the Bayesian interpretation of the T/E-time profiles enabled researchers to obtain a true positive result with a T/E value as low as 2.1 and a true negative result with a T/E ratio as high as 14.2; whereas, any population-based limit in between would have the opposite result. The authors thus propose replacing the population-based limit of current screening tests by a limit that adapts itself as a function of previous test results performed on the individual. This method has already shown its advantages for the analysis of blood doping. The lack of specificity of current screening tests causes unnecessary work for the collection of additional samples and/or analysis with isotope ratio mass spectrometry (IRMS). This lack of specificity is not compensated by a higher sensitivity. The sensitivity of a population-based limit at 4.0 is significantly smaller than the sensitivity obtained by the Bayesian test. For the current study, 12 case studies were selected to represent the possible scenarios to which the anti-doping laboratories are confronted. These case studies were selected from a database of more than 15,000 steroid profiles obtained from routine controls, the collection of steroid profiles of 11 elite athletes monitored for 2 years, and a longitudinal study of 17 amateur athletes, 8 of whom were orally administered testosterone undecanoate pills. 1 table, 2 figures, and 23 references
Main Term(s): Drug testing; Switzerland
Index Term(s): Drug analysis; Drug testing of athletes; Foreign criminal justice research; Steroids
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