skip navigation

PUBLICATIONS

Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.

 

NCJ Number: 228504 Find in a Library
Title: Texas Population Substructure and Its Impact on Estimating the Rarity of Y STR Haplotypes From DNA Evidence
Journal: Jounal of Forensic Sciences  Volume:54  Issue:5  Dated:September 2009  Pages:1016-1021
Author(s): Bruce Budowle, Ph.D.; Jianye Ge, M.S.; Xavier G. Aranda, M.S.; John V. Planz, Ph.D.; Arthur J. Eisenberg, Ph.D.; Ranajit Chakraborty, Ph.D.
Date Published: September 2009
Page Count: 6
Publisher: http://www.wiley.com 
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: In order to provide guidance for calculating the rarity of Y STR (Y chromosome short tandem repeat) haplotypes, 3 sampled populations of unrelated males from the 3 largest subpopulations in Texas - African-America, Caucasian, and Hispanic - were typed for 16 Y STR markers and tested for the degree of substructure within them.
Abstract: The findings confirm that Y STR haplotypes are highly polymorphic and have a high power of discrimination in forensically relevant U.S. populations. The three Texas subpopulations provide data for the upper bound of the effect of population substructure. For haplotypes that comprised at least 10-16 markers, analyses showed the effects of population substructure were small, such that there was little or no need to correct for population substructure when estimating the conditional probability of a Y STR haplotype using the counting method. The counting method with a correction for sampling error was apparently sufficiently conservative; however, estimates of the conditional probability of partial profiles, depending on the number of markers and haplotype sharing, may require a correction for population substructure. The authors recommend a pragmatic maximum Fst value approach or a specific marker Fst value approach for conditional probability estimates for partial profiles where substructure correction is warranted. Both approaches are valid and conservative. The data also indicate that frequency estimates of autosomal and Y STR profiles can be combined by multiplying under the assumption of independence. DNA was obtained from unrelated male donors from paternity-testing cases submitted to the DNA Identification Lab at the University of North Texas Health Science Center, Ft. Worth, TX. Population affinity was assigned by self-reports. The samples consisted of 950 African-Americans, 957 Caucasians, and 1,005 Hispanics. The descriptions of materials and methods address sample collection procedures, sample preparation, Y STR typing, autonomic STR typing, and statistical analyses. 7 tables and 27 references
Main Term(s): Criminology
Index Term(s): Black/African Americans; Caucasian/White Americans; DNA fingerprinting; Forensic sciences; Gender determination; Hispanic Americans; Investigative techniques; Texas
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=250523

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.