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NCJ Number: 228800 Find in a Library
Title: Neurobiological Toll of Child Abuse and Neglect
Journal: Trauma, Violence, and Abuse  Volume:10  Issue:4  Dated:October 2009  Pages:389-410
Author(s): Gretchen N. Neigh; Charles F. Gillespie; Charles B. Nemeroff
Date Published: October 2009
Page Count: 22
Sponsoring Agency: American Heart Assoc
Dallas, TX 75231
National Alliance for Research on Schizophrenia and Depression (NARSAD)
Great Neck, NY 11021
National Institute of Mental Health
Bethesda, MD 20852
National Institutes of Health
Bethesda, MD 20014
Grant Number: MH 039415;MH 42088;MH058922;MH 069056;MH 077083
Type: Literature Review
Format: Article
Language: English
Country: United States of America
Annotation: This article reviews the effects of stressful early life events of child abuse and neglect on the hypothalamic-pituitary-adrenal (HPA) axis, the corticotrophin releasing factor (CRF) system, the subsequent development of mood and anxiety disorders in adulthood, and the potential for transgenerational effects.
Abstract: This article demonstrates that exposure to stress prior to adulthood can result in persistent effects on both mental and physical health. Exposure to violence and abuse can alter the function of the hypothalamic-pituitary-adrenal (HPA) axis throughout one's life, and these changes are accompanied by increased incidence and severity of major depressive disorder, posttraumatic stress disorder, and other anxiety disorders, somatic diseases. The strong and robust effects of early life abuse on lifelong mental and physical health have led to neurobiological theories of potential mechanisms underlying these adverse effects. Alterations in the HPA axis, a major mediating pathway of the stress response, contribute to the long-standing effects of early life trauma. Recognition of the biological consequences and transgenerational impact of violence and abuse has critical importance for both disease research and public health policy. Figures and references
Main Term(s): Long term health effects of child abuse
Index Term(s): Adult survivors of child sexual abuse; Biological influences; Child abuse; Child development; Child emotional abuse and neglect; Child Sexual Abuse; Literature reviews
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