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NCJ Number: 235802 Find in a Library
Title: Analysis of Alprazolam by DART-TOF Mass Spectrometry in Counterfeit and Routine Drug Identification Cases
Journal: Journal of Forensic Sciences  Volume:56  Issue:4  Dated:July 2011  Pages:993-998
Author(s): Warren C. Samms, Ph.D.; Yongyi Julia Jiang, M.S.; Mark D. Dixon, B.S.Chem; Stephen S. Houck, B.S.; Ashraf Mozayani, Ph.D., Pharm.D.
Date Published: July 2011
Page Count: 6
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This article offers the first report of a validated forensic method for confirming alprazolam tablets by direct analysis in real time–time of flight (DART-TOF) mass spectrometric analysis.
Abstract: The high prevalence of alprazolam abuse translates to an increased workload for crime laboratories in characterizing seized tablets. These tablets may originate as diverted pharmaceuticals or counterfeited mimics, so efficient analytical techniques should provide confirmatory data while minimizing destruction of evidence. This technique provides rapid identification of target analytes with minimal sample preparation, allowing direct analysis in the atmospheric sample gap. Selectivity is achieved through high resolution and mass accuracy, unique ion fragments, and chlorine isotopic ratios. This method utilizes fragmentation in two separate voltage functions to observe the alprazolam pseudo molecular ion at 309.09070 using 40 V and major ion fragments of 281.07197 and 205.07657 at 120 V. These parameters allow our laboratory to confirm alprazolam tablets efficiently, without compromising quality forensic standards. (Published Abstract)
Main Term(s): Criminology
Index Term(s): Cost effectiveness analysis; Drug analysis; Drug law enforcement; Forensic sciences; Investigative techniques; Mass spectroscopy; Prescription drugs
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