skip navigation


Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.


NCJ Number: 235812 Find in a Library
Title: Quantitative Method for Simultaneous Determination of 5-Methoxy-N,N-Diisopropyltryptamine and its Metabolites in Urine Using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
Journal: Journal of Forensic Sciences  Volume:56  Issue:4  Dated:July 2011  Pages:1044-1048
Author(s): Ming J. Jin, Ph.D.; Changbae Jin, Ph.D.; Jin Y. Kim, Ph.D.; Moon K. In, Ph.D.; Oh S. Kwon, Ph.D.; Hye H. Yoo, Ph.D.
Date Published: July 2011
Page Count: 5
Sponsoring Agency: Korea Science and Engineering Foundation (KOSEF)
Daejeon 305-350, Korea
Korean Ministry of Education, Science and Technology (MEST)
Seoul, 110-760
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This article discusses the detection of 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) used as recreationally psychedelic drug.
Abstract: 5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a designer hallucinogen derived from tryptamine and is reportedly abused and involved in criminal activities. For the detection of 5-MeO-DIPT use, a liquid chromatography-tandem mass spectrometric method for 5-MeO-DIPT and its metabolites, 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT) and 5-methoxy-N,N-isopropyltryptamine (5-MeO-IPT) was developed and validated in rat urine. The urine samples were pretreated by protein precipitation with acetonitrile and introduced into a BDS HYPERSIL C(18) column (50 x 2.0 mm, 5 um) for chromatographic separation. Mobile phases consisted of methanol, water, and 1percent formic acid, and gradient elution was used at a flow rate of 0.2 mL/min. For the MS detection, multiple-reaction monitoring analysis was adopted. The linear range was 0.01-10 ug/mL, and the lower limit of quantification was 10 ng/mL for all analytes. The intra- and interday accuracies and precisions met the criteria (less than 15 percent). The developed method was successfully applied to the drug-treated rat urine. (Published Abstract)
Main Term(s): Criminology
Index Term(s): Chromatography; Drug analysis; Foreign criminal justice research; Forensic sciences; Hallucinogens; Investigative techniques; Korea (South); Mass spectroscopy; Urinalysis
To cite this abstract, use the following link:

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.