skip navigation


Register for Latest Research

Stay Informed
Register with NCJRS to receive NCJRS's biweekly e-newsletter JUSTINFO and additional periodic emails from NCJRS and the NCJRS federal sponsors that highlight the latest research published or sponsored by the Office of Justice Programs.

NCJRS Abstract

The document referenced below is part of the NCJRS Virtual Library collection. To conduct further searches of the collection, visit the Virtual Library. See the Obtain Documents page for direction on how to access resources online, via mail, through interlibrary loans, or in a local library.


NCJ Number: 236201 Find in a Library
Title: Rapid Screening for the Detection and Differentiation of Gamma-Hydroxybutyrate Using Ion Chromatography
Journal: Journal of Forensic Sciences  Volume:56  Issue:5  Dated:September 2011  Pages:1256-1260
Author(s): Rachel R. Hughes, B.Sc.; G. Stewart Walker, Ph.D.
Date Published: September 2011
Page Count: 5
Sponsoring Agency: Flinders University, South Australia
Adelaide 5001,
South Australian Justice Dept
Adelaide SA 5001 ,
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: This paper presents a new method utilizing ion-exchange chromatography (IC) with conductivity detection.
Abstract: The analysis of gamma-hydroxybutyric acid (GHB) is problematic because it is hygroscopic, it lacks a good UV chromophore, and it undergoes heat-induced cyclization. This paper presents a new method utilizing ion-exchange chromatography (IC) with conductivity detection. The simple sample preparation, rapid analysis time, and inorganic anion detection capabilities are all advantages over the current methods. The detection of inorganic salts (formed during GHB synthesis) gives insight into the synthetic route utilized and can aid in drug seizure comparison. The developed method has a detection limit for GHB anions of 0.57 mg/L and chloride of 0.22 mg/L. A comparison of this technique with a current gas chromatography–mass spectrometry technique is presented, and a t-test found that the two methods’ results are not statistically different at the 99.9 percent confidence level demonstrating the merits of this fast, simple, and informative IC method as a routine screening tool. (Published Abstract)
Main Term(s): Criminology
Index Term(s): Australia; Chromatography; Comparative analysis; Drug analysis; Drug detection; Foreign criminal justice research; Forensic sciences; GHB (gammahydroxybutyrate); Investigative techniques
Note: Presented in part at the 19th Australian and New Zealand Forensic Science Society (ANZFSS) International Symposium on the Forensic Sciences, October 6–9, 2008, in Melbourne, Australia; at the 16th RACI R&D Topics Conference, December 8–10, 2008, in Sydney, Australia; at the 42nd IUPAC Congress, August 2–7, 2009, in Glasgow, Scotland, U.K.; and at the 20th ANZFSS International Symposium on the Forensic Sciences, September 5–9, 2010, in Sydney, Australia.
To cite this abstract, use the following link:

*A link to the full-text document is provided whenever possible. For documents not available online, a link to the publisher's website is provided. Tell us how you use the NCJRS Library and Abstracts Database - send us your feedback.