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NCJ Number: 236878 Find in a Library
Title: Development of Microwave-Assisted Extraction Procedure for Organic Impurity Profiling of Seized 3,4-Methylenedioxymethamphetamine (MDMA)
Journal: Journal of Forensic Sciences  Volume:56  Issue:6  Dated:November 2011  Pages:1483-1492
Author(s): Patricia J. Giebink, M.D.; Ruth Waddell Smith, Ph.D.
Date Published: November 2011
Page Count: 10
Sponsoring Agency: Forensic Sciences Foundation
Colorado Springs, CO 80904
Publisher: http://www.wiley.com 
Type: Report (Study/Research)
Format: Article
Language: English
Country: United States of America
Annotation: In this research, the development of an alternative microwave-assisted extraction/headspace solid-phase microextraction (MAE/HS-SPME) procedure is described.
Abstract: Organic impurity profiling of seized 3,4-methylenedioxymethamphetamine (MDMA) tablets aims to link tablets to common production sources. Conventionally, organic impurities are extracted from tablets using a liquid–liquid extraction (LLE) procedure prior to analysis by gas chromatography–mass spectrometry (GC-MS). In this research, the development of an alternative microwave-assisted extraction/headspace solid-phase microextraction (MAE/HS-SPME) procedure is described. The optimal procedure used phosphate buffer (1 M, pH 8), with an HS-SPME extraction temperature of 70°C for 40 min, using a divinylbenzene/Carboxen™/polydimethylsiloxane (DVB/CAR/PDMS) fiber. Impurities were extracted from seized MDMA exhibits using the MAE/HS-SPME procedure, as well as HS-SPME alone, and a conventional LLE procedure. The HS-SPME procedure was deemed to be the most practical because of the affordability and need for less analyst involvement. Although the LLE was limited in the number of impurities extracted, the procedure is still useful for the extraction of less volatile impurities that are not extracted by HS-SPME. (Published Abstract)
Main Term(s): Criminology
Index Term(s): Chromatography; Drug detection; Mass spectroscopy; MDMA (designer drug)
Note: Presented at the 61st American Academy of Forensic Sciences Annual Meeting, February 16–21, 2009, in Denver, CO
To cite this abstract, use the following link:
http://www.ncjrs.gov/App/publications/abstract.aspx?ID=258898

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