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NCJ Number: 83182 Add to Shopping cart Find in a Library
Title: Genetic Markers in Human Semen - A Review
Journal: Journal of Forensic Sciences  Volume:21  Issue:4  Dated:(1976)  Pages:784-796
Author(s): E T Blake; G F Sensabaugh
Date Published: 1976
Page Count: 13
Sponsoring Agency: US Dept of Justice

US Dept of Justice
Washington, DC 20531
US Dept of Justice NIJ Pub
Washington, DC 20531
Grant Number: 74NI-99-0041; 75NI-99-0036
Format: Article
Language: English
Country: United States of America
Annotation: The current state of knowledge on the expression of genetic variation in human semen is reviewed, and the practical problems of the forensic analysis of semen are considered.
Abstract: Basically, the genetic markers of semen are partitioned into two categories: the cell surface antigens and the proteins and enzymes. These categories reflect the chemical nature of the markers and the methods used for their detection. The cell surface antigens, for example, are detected by immunological procedures, usually agglutination reactions or some variation thereof. In the context of the discussion, the soluble ABO antigens found on the soluble secretor substances are considered 'honorary' cell surface antigens. Genetic variation of proteins and enzymes, on the other hand, is usually detected by electrophoretic procedures. Both intracellular and extracellular proteins and enzymes are included in this category. Also included are the immunoglobulin markers Gm and Inv, for although they are detected by immunological procedures, they are carried on soluble proteins. Neither category of genetic variation is without unresolved problems. The genetic typing of semen is not nearly as straightforward as the genetic typing of blood. There are unique problems of sample collection, sample dilution, contamination, and degradation. Recognition of these problems is the first step toward their solution, and with continued research, progress toward the practical use of genetic typing of semen will be made. Photographic illustrations and 38 references are provided. (Author summary modified)
Index Term(s): Blood/body fluid analysis
Note: This article was presented at the 28th Annual Meeting of the American Academy of Forensic Sciences in Washington, DC, February 16-20, 1976.
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