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NCJ Number: NCJ 175661     Find in a Library
Title: Evaluation of Analytical Methodologies for Non-Intrusive Drug Testing: Supercritical Fluid Extraction of Cocaine From Hair
  Document URL: PDF 
Author(s): J F Morrison ; L T Sniegoski ; W J Yoo
Corporate Author: National Institute of Standards and Technology (NIST)
United States of America
Date Published: 1999
Page Count: 26
  Annotation: Supercritical fluid extraction (SFE) was investigated to determine whether it can be an environmentally friendly alternative to the currently used wet chemical procedures in hair drug-testing protocols.
Abstract: The SFE behavior of cocaine and its primary metabolite benzoylecgonine was studied and found to be highly dependent on the nature of the matrix and the manner in which the target drug analytes were incorporated into or on the matrix. The dependence of extractability on hair/drug binding interactions allowed the differentiation of cocaine present at different discrete sites in hair based on differences in SFE behavior, suggesting the potential for distinguishing exogenous (i.e., environmental) from endogenous (i.e., physiological) sources of drugs in hair by using sequential extraction under differing SFE conditions. SFE using pure carbon dioxide was found to be superior to existing liquid decontamination methods for the removal of vapor-deposited cocaine from the surface of hair. Addition of an SFE modifier mixture that contained triethylamine and water allowed the recovery of "matrix-bound" cocaine from hair-binding sites, and extraction efficiencies compared favorably with existing liquid- based extraction procedures. Extraction times in SFE were approximately 30 minutes to 50 minutes, compared with several hours to 1 day for currently used liquid methods. Based on the extraction results observed on drug-fortified and drug-user hair, a displacement SFE mechanism is proposed in which triethylamine competes with cocaine hair-binding sites. The SFE results additionally provide insight into the nature of hair-drug binding interactions and lend support to a current model for drug incorporation in hair. 3 tables, 9 figures, and 30 references
Main Term(s): Drug testing
Index Term(s): Cocaine ; Hair and fiber analysis
Sponsoring Agency: US Dept of Justice
National Institute of Justice
Office of Science and Technology
United States of America
Publication Number: NIJ Report 601-98
Sale Source: NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America

National Law Enforcement and Corrections Technology Center (NLECTC)
700 N. Frederick Ave.
Bldg. 181, Room 1L30
Gaithersburg, MD 20879
United States of America
Type: Report (Technical)
Country: United States of America
Language: English
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