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NCJ Number: NCJ 195986     Find in a Library
Title: Susceptibility of PharmChek(TM) Drugs of Abuse Patch to Environmental Contamination
  Document URL: PDF 
Author(s): David A. Kidwell Ph.D. ; Frederick P. Smith Ph.D.
Corporate Author: University of Alabama at Birmingham
Dept of Justice Sciences
United States of America

US Naval Research Laboratory
Chemical Division, Code 6177
United States of America
Date Published: 2002
Page Count: 24
  Annotation: This paper explores some of the variables affecting how drugs from the external environment can enter the sweat collection patch, affecting reliability results and proposes improvements in the design and use of the sweat patch to reduce external contamination from the outside and detect contamination from within.
Abstract: It has been well documented that ingested drugs appear in sweat. A sweat collection patch marketed by PharmChem, Inc. as the PharmChek(TM) Drugs of Abuse patch was developed through the joining of a non-occlusive membrane with a collection pad for use in drug detection. Sweat collection devices sandwich an absorbent pad between the skin and an outer membrane using a tamper-evident adhesive backing on the membrane. The cleansing of the skin prior to application of the patch aids in reducing the potential for bacterial growth and skin contamination. This patch is perceived by the criminal justice system as having wide application due to its user friendliness, non-invasiveness, easily observed placement and removal, detectable adulteration attempts, long drug-use detection interval of approximately 1 week while being worn, and the potential to identify unique metabolites. However, there have been questions regarding the reliability of results from the sweat patch due to external contamination from without, or outside the patch (CFWO) or from the prior presence of drugs on the exterior of the skin, not removed by the cleaning process (external contamination from within, under the patch- CFWI). This paper explored how these variables affect the reliability in detecting the use of drugs. Findings indicated that with the current design of the sweat patch problems with CFWO and CFWI could occur. A recommendation was presented to redesign the patch with an air gap to reduce the CFWO. Saving the swabs used for cleansing the skin (with possible inclusion of mild acid in the isopropanol) for testing can improve interpretations. In addition, following up on an individual who denies drug use with frequent urine tests will assist in improving reliability and respond to CFWO and CFWI. Continued research on sweat patch tests is recommended. Figures and references
Main Term(s): Drug testing
Index Term(s): Drug abuse ; Urinalysis ; Drug prevention programs ; Drug use ; Drug analysis ; Criminalistics ; Controlled Substances ; Forensics/Forensic Sciences ; NIJ grant-related documents
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America

Office of National Drug Control Policy
United States of America
Grant Number: 2000-RD-VX-A038
Sale Source: NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America

US Naval Research Laboratory
Chemical Division, Code 6177
Washington, DC 20375
United States of America
Type: Report (Study/Research)
Country: United States of America
Language: English
Note: See NCJ-196030 for Final Report.
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