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NCJ Number: NCJ 210417   Add to Shopping cart   Find in a Library
Title: Detection of Date Rape Drugs by Capillary Electrochromatography
  Document URL: PDF 
Author(s): Bruce McCord
Date Published: 06/2003
Page Count: 68
  Annotation: This report describes the methodologies and findings of a series of studies that demonstrated the promising applications of capillary electrophoresis (CE) in the detection of drugs used to incapacitate victims of sexual assault.
Abstract: In recent years, a number of forensic laboratories have begun using CE as an alternative to gas chromatography with nitrogen phosphorus (GC/NPD) to screen for drugs difficult to detect with standard immunoassay techniques. The advantages of CE over traditional drug-screening tools are its simplicity, resistance to fouling, and ability to detect highly polar compounds; however, neutral drugs like benzodiazepines and those with similar structures such as opiates can be difficult to separate with standard CE techniques. Other compounds such as GHB can exist in acidic and neutral forms (GBL), further complicating their analysis. Many of these compounds have been involved in drug-facilitated sexual assaults. The current series of studies explored recently developed electrochromatographic methods to improve the detection of these compounds, including micellar electrochromatography, cyclodextrin-based inclusion complexes, and monolithic stationary phases. These techniques were used to develop a number of novel methods for the detection of drugs implicated in sexual assaults, including GHB, benzodiazepines, amphetamines, cocaine, and heroin. In addition, the researchers developed new procedures that used fluorescence derivatization and inline extraction to improve the detection of trace levels of these drugs in biological fluids. Also, microfluidic approaches were investigated in the interest of providing an inexpensive implementation of these techniques in small forensic laboratories. Overall, the experiments demonstrated an exceptional flexibility and range of applications for CE in detecting "date-rape drugs." 33 figures, 4 tables, 58 references, and appended list of 6 papers published and in preparation based on this work
Main Term(s): Drug analysis
Index Term(s): Criminal methods ; Drug Related Crime ; Rape investigations ; Forensics/Forensic Sciences ; Investigative techniques ; Rape causes ; Acquaintance rape ; NIJ final report
Sponsoring Agency: National Institute of Justice (NIJ)
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2002-MU-MU-K002
Sale Source: National Institute of Justice/NCJRS
Box 6000
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Type: Report (Study/Research)
Country: United States of America
Language: English
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