A successful response to alcohol and other drug use entails coordination among multiple service providers who interact with at-risk individuals. State agencies need to cooperate with each other in developing public policies and programs that address prevention and treatment. Agencies responsible for services include maternal and child health, alcohol and other drug prevention and treatment, child welfare, education, mental health, housing, and corrections. Each agency plays an integral role in addressing the problem of drug abuse and dependency as it influences families. In addition, consumer advocacy groups, businesses, professionals, elected officials, foundations, local leaders, and consumers should work with agencies to define the problem and develop an appropriate response. Activities of State service systems most prominently involved in reducing the impact of alcohol and other drug use on families are described, and guidelines for establishing collaborative efforts are offered. Appendixes list State Title V directors, State alcohol and drug agency directors, and State child welfare commissioners and/or directors.