The National Career Information System is located in the Center for the Advancement of Technology in Education at the University of Oregon. This organization provides software, occupational and educational information, and technical assistance to clients in 16 States. Each client agency then localizes the information and offers the program and associated training to schools and agencies in that State. The schools and agencies, in turn, provide the program to their students and clients. The end users, the students, use this computer program and associated printed material for interactive exploration of occupational choice, occupational information, secondary and postsecondary educational information, financial aid information, and job- seeking and entrepreneurial skills development. The software, information, and training approaches are known collectively as the Career Information System (CIS). The goal of the study reported in this article was to identify successful strategies for using the CIS with at-risk youth (youth who had dropped out of high school or were in danger of doing so). The author describes two successful programs, presents guidelines for the design of career development programs for at-risk youth, and discusses why CIS works with them. 6 references