Although alcohol is present in a significant proportion of violent events, understanding of the mechanisms by which alcohol influences violent behavior has been limited, largely because the causes are multifactorial and include interacting pharmacological, endocrinological, genetic, situational, environmental, and sociocultural determinants. Theoretical explanations of alcohol-induced violence have tended to focus on only one aspect of the problem, and in turn, efforts to prevent such violence have been hampered. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites research grant applications that advance understanding of the biological and psychosocial mechanisms underlying associations between alcohol consumption and interpersonal violence and that identify and test interventions to reduce and/or prevent alcohol-related violence and the alcohol-related sequelae of such violence. Of primary interest are studies that identify: individual and environmental conditions, situations, populations, and circumstances under which alcohol and violence are causally connected; sequential processes by which alcohol intake may lead to violent behavior and vice versa; physiological and neural mechanisms that mediate the relationship between alcohol and violence; behavioral consequences of alcohol- related violence, including subsequent alcohol abuse and violent behavior; and interventions that may effectively reduce alcohol-related violence. Eligibility and application requirements, addresses and telephone numbers, as well as review and award criteria are provided. A summary of the research to date concerning the alcohol-violence relationship is presented. Also discussed briefly in this announcement is the Public Health Service's (PHS) "Healthy People 2000" program, a PHS-led national activity for setting various priority areas. The address for obtaining a copy of "Healthy People 2000" is provided. References