Criteria for inclusion in the CBT program included at least 20 percent of school days missed in the 4 weeks prior to the initial assessment, postpubertal based on a physical examination, diagnosis of one or more anxiety disorders and major depressive disorder, and a diagnosis of problematic anxiety. The sample included 23 females and 18 males aged 12 to 18. A hierarchical multiple regression analysis was used to assess the following variables as possible predictors of treatment response as measured by school attendance at the end of treatment: baseline severity (school attendance at baseline), drug group (imipramine versus placebo), presence of separation anxiety disorder (SAD), and the presence of avoidant disorder (AD). The study found that baseline school attendance, CBT plus imipramine, SAD, and AD were significant predictors of treatment response and accounted for 51 percent of the variance in outcome. A higher rate of school attendance at baseline and the reception of imipramine predicted a better response to treatment; whereas, the presence of SAD and AD predicted a poorer response to treatment. The relationship between sociodemographic variables and treatment outcome was also assessed. Age and socioeconomic status were unrelated to school attendance after treatment. Males had significantly higher rates of attendance after treatment than did the females. The study concludes that adolescents with a school-attendance problem are a heterogeneous population and require individualized treatment planning. Variables such as diagnosis and severity of symptoms at the start of treatment should be taken into consideration when planning treatment. Directions are suggested for future research. 1 table and 53 references