Research suggests a number of commonalities among child maltreatment, youth violence, and adult domestic violence in terms of the populations affected as well as the factors that cause and prevent their occurrence. Crafting a research framework that facilitates the identification and dissemination of promising practice and policy innovations across all three forms of violence seems eminent and logical. The goal of this article is to set forth an overarching framework and specific hypothesis that researchers can use to develop collaborative avenues of study. The article begins by reviewing what is known about the commonalities across all three forms of violence and discussing crosscutting issues that have some relevance in advancing the understanding of violence and its effects on personal and social interactions. Current trends in the treatment, prevention, and research arenas offer multiple and beneficial opportunities for building a more coordinated and effective response to the system of violence production. Efforts to better unravel the unique role that interpersonal violence plays in shaping a child’s, youth’s, adult’s, or family’s development trajectory offer opportunities to construct a more respectful, and potentially more effective response system.