Depression, hostility, and sleep disturbance should be evaluated for all women who have experienced violence. Each of these effects should be addressed in treatment, since reduction in symptoms will improve overall health. Research on violence against women should include measures to enhance the immune system, especially treatment with pro-inflammatory cytokines, particularly IL-1beta, IL-6, and TNF-alpha. Depression is one of the most common harms to victims of abuse and violence. Depression in turn apparently suppresses the immune system and has been linked to coronary heart disease, myocardial infarction, chronic pain syndromes, premature aging, and even Alzheimer's disease. Women victims of violence and abuse also tend to develop a hostile view of the world. They bring mistrust to their relationships, along with suspiciousness, cynicism about human nature, and a tendency to interpret the actions of others as aggressive. A hostile worldview and associated strife in intimate relationships increase the risk of cardiovascular disease and metabolic syndrome. These conditions can lead to premature mortality in abuse survivors who have a hostile worldview. At least two studies found that women were particularly susceptible to these adverse health effects. Disturbed sleep is frequently a consequence for women who have experienced abuse and violence. Sleep disturbance can increase the effects of depression and posttraumatic stress disorder, which can increase health problems and decrease quality of life. 52 references