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NCJ Number: NCJ 225533   Add to Shopping cart   Find in a Library
Title: Development of Microfluidic Devices for the Rapid Isolation and Detection of Drugs of Abuse
Author(s): Bruce McCord ; Carla Turner ; Maximilien Blas ; Sandra Bishop ; Maggie Lerch ; Sacha Dehere ; Roberto Pannepucci
Date Published: 2008
Page Count: 76
Sponsoring Agency: National Institute of Justice
US Department of Justice
Office of Justice Programs
United States of America
Grant Number: 2004-WG-BX-K077
Sale Source: National Institute of Justice/NCJRS
Box 6000
Rockville, MD 20849
United States of America

NCJRS Photocopy Services
Box 6000
Rockville, MD 20849-6000
United States of America
Document: PDF 
Type: Report (Technical) ; Test/Measurement
Language: English
Country: United States of America
Annotation: This report describes the methodology and outcomes for a project designed to test the use of microchip-based devices for separating and analyzing drug compounds that have been implicated in drug-facilitated sexual assault, including phenethyl amines, GHB, and benzodiazepines.
Abstract: The project demonstrates the feasibility of using micro fluidic devices as a rapid screening tool for the detection of benzodiazepines used in beverages for committing drug-facilitated sexual assault (DFSA); however, for use in court, more definitive techniques are required. CEC/MS (capillary electrochromatography mass spectrometry) provides this capability in a micro fluidic format. Procedures developed for publication in the forensic literature include a micro fluidic procedure for the indirect detection of nitro benzodiazepines, a procedure for the trace detection of phenethyl amines using chip detection, an online preconcentration technique for the detection of a wide variety of drugs in urine using CE, a technique for the ultra trace detection of benzodiazepines by CEC/MS, and the development of chip-based designs for improved resolution of samples by fluorescent and electrochemical detection. Future work will continue to expand the application of chip-based screening and CEC/MS-TOF techniques to other drugs implicated in DFSA. This will minimize sample requirements and provide sensitive, disposable analytical systems for high throughput analysis. This report provides a detailed description of the methods used to achieve the detection of phenethyl amines on micro fluidic devices, the indirect detection of benzodiazepines, and the use of CEC/MS and monolithic CEC/MS-TOF for inline extraction. 9 tables, 18 figures and 74 references
Main Term(s): Drug analysis
Index Term(s): Chromatography ; Drug detection ; Criminal methods ; Sexual assault ; Mass spectroscopy ; Drug Related Crime ; Investigative techniques ; NIJ final report
   
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https://www.ncjrs.gov/App/Publications/abstract.aspx?ID=247515

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