Results suggest that ice methamphetamine trafficking and abuse are the most significant drug threats to the Northern California HIDTA region. More drug-related crimes, including violent crimes and property crimes, are attributed to methamphetamine trafficking and abuse than to any other illicit drug. Mexican drug trafficking organizations (DTOs) are the primary transporters and distributors of the drug. Methamphetamine super lab seizures have increased in the last 2 years; large-scale pseudoephedrine “smurfing” operations by Mexican DTOs and criminal groups that employ numerous individuals to purchase cold medications from local retailers are the likely sources of precursor chemical supplies for these super labs. Cannabis cultivation has increased dramatically in the region over the last 5 years, making it one of the most prominent marijuana production areas in the Nation. This report was prepared through detailed analysis of recent law enforcement reporting, information obtained through interviews with law enforcement and public health officials, and available statistical data. Tables, figures, and list of sources