In October 2006, the International Symposium on the Biomedical Side Effects of Doping was held in Munich, Germany to address the increasing incidence of doping violations in the world of sports. The papers in this manual discuss the actual state of knowledge among the international community regarding doping related issues and health hazards in the world of sports. Participants in the symposium came from 22 nations and included scientists, coaches, physicians, politicians, and other interested stakeholders. The manual is divided into seven sections. The first two sections discuss 1) the International Convention Against Doping in Sport developed by the United Nations Educational, Scientific and Cultural Organization (UNESCO), and 2) the doping issue in the world of sports. The third section contains eight papers the health side effects of doping substances on different parts of the human anatomy: the supporting apparatus and musculoskeletal system, the cardiovascular system, the respiratory system, the gastrointestinal tract and liver, the reproductive and endocrine systems, renal disorders and electrolyte metabolism, the immune system and skin, and psychological effects and addition. The fourth section contains four papers on specific topics of interest: nutritional supplements, gene doping, narcotics, and cannabinoids. Sections 5, 6, and 7 contain papers that discuss the Knowledge of Different Target Groups in the Fight Against Doping, Doping in Handicapped Sport, and Prevention Strategies.