Prevention activities that have been implemented in schools throughout the country are presented in various studies. The author classified these diverse prevention activities into five educational domains: cognitive, behavioral, affective/interpersonal, environmental, and therapeutic. Each domain is defined, and research findings for each are discussed. Results indicate that most substance abuse-prevention education has not been effective in preventing or delaying the onset of drug or alcohol use and abuse among juveniles. Studies show that behavioral training in relevant social skills, such as resistance or assertiveness training, can prevent the onset of cigarette smoking and possibly the use of alcohol and marijuana by junior high school students. It is recommended that further research be conducted to determine why these strategies work, for whom they work best, the duration of positive effect, and the conditions required for effective implementation of these curricula within operational school settings. 62 references.