The report presents national estimates of the rates of use, numbers of users, and other measures related to illicit drugs, alcohol, and tobacco products. The report focuses on trends between 2009 and 2010 and from 2002 to 2010, as well as differences across population subgroups in 2010. Survey responses indicate that in 2010, an estimated 22.6 million Americans ages 12 or older were current (past month) illicit drug users, meaning they had used an illicit drug during the month prior to the survey interview. Illicit drugs covered in the survey were marijuana/hashish, cocaine, heroin, hallucinogens, inhalants, or prescription-type psychotherapeutics used nonmedically. Slightly more than half of Americans aged 12 or older reported being current drinkers of alcohol in the 2010 survey. In 2010, an estimated 69.6 million Americans aged 12 or older were current (past month) users of tobacco products (27.4 percent of the population). In 2010, an estimated 22.1 million persons (8.7 percent of the population ages 12 or older) were classified with substance dependence or abuse in the past year based on criteria specified in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Of these, 2.9 million were classified with dependence or abuse of alcohol and illicit drugs, 4.2 million had dependence or abuse of illicit drugs but not alcohol, and 15 million had dependence or abuse of alcohol but not illicit drugs. Extensive tables and figures